Which antibiotic is listed as a first-line option for maternal GBS prophylaxis during labor?

Which antibiotic is listed as a first-line option for maternal GBS prophylaxis during labor?

• A. Penicillin G
• B. Erythromycin
• C. Azithromycin
• D. Ampicillin

Answer: (A)

Preventing transmission of Group B Streptococcus from mother to baby during labor is the goal of intrapartum prophylaxis, andPenicillin G is the preferred agent because it reliably covers GBS with a strong safety record for both mother and newborn. GBS remains highly susceptible to penicillin, so using this antibiotic provides effective protection with minimal risk of resistance. Alternatives like erythromycin or azithromycin are not as reliable due to rising resistance among GBS strains, which can lead to ineffective prophylaxis. Ampicillin can be used if penicillin G isn’t suitable, but it isn’t the first-line choice because penicillin G has the narrowest spectrum and the most proven track record for this specific purpose.

Preventing transmission of Group B Streptococcus from mother to baby during labor is the goal of intrapartum prophylaxis, andPenicillin G is the preferred agent because it reliably covers GBS with a strong safety record for both mother and newborn. GBS remains highly susceptible to penicillin, so using this antibiotic provides effective protection with minimal risk of resistance. Alternatives like erythromycin or azithromycin are not as reliable due to rising resistance among GBS strains, which can lead to ineffective prophylaxis. Ampicillin can be used if penicillin G isn’t suitable, but it isn’t the first-line choice because penicillin G has the narrowest spectrum and the most proven track record for this specific purpose.